Irodalom:
1*. T Ishii, J Murakami, K Notohara, és mtsai: Oesophageal squamous cell carcinoma may develop within
a background of accumulating DNA methylation in normal and dysplastic mucosa. Gut 2007;56:13-19.
2. Baumann S, Keller G, Puhringer F és mtsai: The prognostic impact of O6-Methylguanine-DNA
Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma. Int J Cancer
2006;119:264-8.
Genetika 433
3. Liu HX, Li Y, Jiang XD, Yin HN, et al: Mutation screening of mismatch repair gene Mlh3 in familial
esophageal cancer. World J Gastroenterol 2006; 12:5281-5286.
4. Luthra R, Wu TT, Luthra MG, és mtsai: Gene Expression Profiling of Localized Esophageal
Carcinomas: Association With Pathologic Response to Preoperative Chemoradiation. J Clin Oncol
2006; 24:259-267.
5. Hao Y, Triadafilopoulos G, Sahbaie P és mtsai: Gene Expression Profiling Reveals Stromal Genes
Expressed in Common Between Barrett’s Esophagus and Adenocarcinoma. GASTROENTEROLOGY
2006;131:925-933
6. Hage M, Siersema PD, Vissers KJ és mtsai: Genomic analysis of Barrett’s esophagus after ablative
therapy: Persistence of genetic alterations at tumor suppressor loci. Int J Cancer 2006;118:155-60.
7. Hamilton JP, Meltzer SJ.: A Review of the Genomics of Gastric Cancer. Clin Gastroenterol Hepatol
2006;4:416-25.
8. Wang L, Zhu JS, Song MQ, és mtsai: Comparison of gene expression profi les between primary tumor
and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
World J Gastroenterol 2006; 12: 6949-6954.
9. Shirai K, Ohmiya N, Taguchi A és mtsai: Interleukin-8 gene polymorphism associated with susceptibility
to non-cardia gastric carcinoma withmicrosatellite instability. J Gastroenterol Hepatol 2006;21:1129-35.
10. Park DH, Yun JW, Park JH és mtsai: HER-2/neu Amplification Is an Independent Prognostic Factor in
Gastric Cancer. Dig Dis Sci 2006;51:1371-9.
11. Miao X, Zhang X, Zhang L és mtsai: Adenosine Diphosphate Ribosyl Transferase and X-Ray Repair
Cross-Complementing 1 Polymorphisms in Gastric Cardia Cancer. GASTROENTEROLOGY
2006;131:420-427.
12. Liu F, Pan K, Zhang X és mtsai: Genetic Variants in Cyclooxygenase-2: Expression and Risk of Gastric
Cancer and Its Precursors in a Chinese Population. GASTROENTEROLOGY 2006;130:1975-1984.
13. Yi SY, Lee WJ.: A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer
and advanced gastric cancer. World J Gastroenterol 2006; 12: 6536-6539.
14. Lacasana-Navarro, Galvan-Portillo M, Chen J, Lopez-Cervantes M és mtsai:
Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in
Mexico. Eur J Cancer 2006;42:528-33.
15. B Streubel, G Seitz, M Stolte és mtsai: MALT lymphoma associated genetic aberrations occur at different
frequencies in primary and secondary intestinal MALT lymphomas. Gut 2006;55:1581-1585.
16. Brucher1 BLDM, Geddert H, Langner C és mtsai: Hypermethylation of hMLH1, HPP1, p14ARF,
p16INK4A and APC in primary adenocarcinomas of the small bowel. Int J Cancer 2006;119:1298-1302.
17. Sutter AP, Fechner H.: Gene therapy for gastric cancer: Is it promising? World J Gastroenterol 2006;
12 (3): 380-387.
18. Shuai XM, Han GX, Wang GBés mtsai: Cyclin D1 antisense oligodexoyneucleotides inhibits growth
and enhances chemosensitivity in gastric carcinoma cells. World J Gastroenterol 2006; 12: 1766-1769.
19. Van Oijen MGH, Laheij RJF, Koetsier M és mtsai: Effect of a Specific Cyclooxygenase-Gene Polymorphism
(A-842G/C50T) on the Occurrence of Peptic Ulcer Hemorrhage. Dig Dis Sci 2006;51: 2348-2352.
20. T Ando, E M El-Omar, Y Goto, és mtsai: Interleukin 1B proinflammatory genotypes protect against
gastro-oesophageal reflux disease through induction of corpus atrophy. Gut 2006;55:158-164.
21. Leung WK, Chan MCW, To KF és mtsai: H. pylori Genotypes and Cytokine Gene Polymorphisms
Influence the Development of Gastric Intestinal Metaplasia in a Chinese Population. Am J
Gastroenterol 2006;101:714-720.
22. Zabaleta J, Camargo MC, Piazuelo MB és mtsai: Association of Interleukin-1β Gene Polymorphisms
with Precancerous Gastric Lesions in African Americans and Caucasians. Am J Gastroenterol
2006;101:163-171.
434 Gastro Update 2007
23. KA Hunt, AJ Monsuur,WL McArdle és mtsai: Lack of association of MYO9B genetic variants with
coeliac disease in a British cohort. Gut 2006;55:969-972.
24. Rueda B, Nunez C, Lopez-Nevot MA és mtsai: Functional polymorphism of the NFKB1 gene promoter
is not relevant in predisposition to celiac disease. Scand J Gastroenterol 2006;41:420-3.
25. Jore RD, Frau F, Cucca F és mtsai: HLA-DQB1*0201 homozygosis predisposes to severe intestinal
damage in celiac disease. Scand J Gastroenterol 2006;41:48-53.
26. Lakatos PL, Lakatos L.: A herediter és sporadikus colorectalis daganatok genetikája és a genetikai
ismeretek jelentõsége a mindennapi gyakorlatban — I. Orv Hetil 2006;147:363-9.
27. Lakatos PL, Lakatos L.: A herediter és sporadikus colorectalis daganatok genetikája és a genetikai
ismeretek jelentõsége a mindennapi gyakorlatban — II. Orv Hetil 2006;147:449-56.
28. Maple JT, Boardman LA.: Genetics of colon polyposis. Clin Gastroenterol Hepatol 2006;4: 831-5.
29. Aretz1 S, Uhlhaas S, Goergens H és mtsai: MUTYH-associated polyposis: 70 of 71 patients with biallelic
mutations present with an attenuated or atypical phenotype. Int J Cancer 2006;119:807-14.
30. Cardoso J, Molenaar L, de Menezes RX és mtsai: Chromosomal Instability in MYH- and APC-Mutant
Adenomatous Polyps. Cancer Res 2006; 66: 2514-9.
31. H Mehenni, N Resta, JG Park és mtsai: Cancer risks in LKB1 germline mutation carriers. Gut
2006;55:984-990.
32. RC Niessen, MJW Berends, Y Wu, és mtsai: Identification of mismatch repair gene mutations in young
patients with colorectal cancer and in patients with multiple tumours associated with hereditary nonpolyposis
colorectal cancer. Gut 2006;55:1781-1788.
33*. Goecke T, Schulmann K, Engel C és mtsai: Genotype-Phenotype Comparison of German MLH1 and
MSH2 Mutation Carriers Clinically Affected With Lynch Syndrome: A Report by the German HNPCC
Consortium. J Clin Oncol 2006; 24:4285-4292.
34. Tanyi M, Olasz J, Lukács G, és mtsai: Pedigree and genetic analysis of a novel mutation carrier patient
suffering from hereditary nonpolyposis colorectal cancer. World J Gastroenterol 2006; 12: 1192-1197
35*. P Minoo, K Baker, R Goswami, és mtsai: Extensive DNA methylation in normal colorectal mucosa in
hyperplastic polyposis. Gut 2006;55:1467-1474.
36*. Spring KJ, Zhao ZZ, Karamatic R és mtsai: High Prevalence of Sessile Serrated Adenomas With BRAF
Mutations: A Prospective Study of Patients Undergoing Colonoscopy. GASTROENTEROLOGY
2006;131:1400-1407.
37. Chow E, Lipton L, Lynch E és mtsai: Hyperplastic Polyposis Syndrome: Phenotypic Presentations and
the Role of MBD4 and MYH. GASTROENTEROLOGY 2006;131:30-39.
38. Kemp ZE, Carvajal-Carmona LG, Barclay E és mtsai: Evidence of Linkage to Chromosome 9q22.33
in Colorectal Cancer Kindreds from the United Kingdom. Cancer Res 2006; 66: 5003-6.
39. Martinez ME, Thompson P, Jacobs ET és mtsai: Dietary Factors and Biomarkers Involved in the
Methylenetetrahydrofolate Reductase Genotype—Colorectal Adenoma Pathway. GASTROENTEROLOGY
2006;131:1706-1716.
40. Little J, Sharp L, Masson LF és mtsai: Colorectal cancer and genetic polymorphisms of CYP1A1,
GSTM1 and GSTT1: A case-control study in the Grampian region of Scotland. Int J Cancer
2006;119:2155-64.
41. Sinicrope FA, Rego RL, Halling KC és mtsai: Prognostic Impact of Microsatellite Instability and DNA
Ploidy in Human Colon Carcinoma Patients. GASTROENTEROLOGY 2006;131:729-737.
42. R Jover, P Zapater, A Castells és mtsai: Mismatch repair status in the prediction of benefit from adjuvant
fluorouracil chemotherapy in colorectal cancer. Gut 2006;55:848-855.
43. Sawnhey MS, Farrar WD, Gudiseva S és mtsai: Microsatellite Instability in Interval Colon Cancers.
GASTROENTEROLOGY 2006;131:1700-1705.
44. Sincrope FA, Rego RL, Foster N és mtsai: Microsatellite Instability Accounts for Tumor Site-Related
Genetika 435
Differences in Clinicopathologic Variables and Prognosis in Human Colon Cancers. Am J
Gastroenterol 2006;101:2818-2825.
45. Watanabe T, Kobunai T, Toda E és mtsai: Distal Colorectal Cancers with Microsatellite Instability
(MSI) Display Distinct Gene Expression Profiles that Are Different from Proximal MSI Cancers.
Cancer Res 2006;66:9804-8.
46. DA Lawes, T Pearson, S SenGupta és mtsai: Is MSI-H of value in predicting the development of
metachronous colorectal cancer? Eur J Cancer 2006; 42:473-6.
47. Fan Y, Liu X, Zhang H és mtsai: Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal
cancer in a Chinese population. Cancer Genet Cytogenet 2006;170:121-8.
48. S Ogino, M Cantor, T Kawasaki és mtsai: CpG island methylator phenotype (CIMP) of colorectal cancer
is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut
2006;55:1000-1006.
49. Goel A, Nagasaka T, Arnold CN és mtsai: The CpG Island Methylator Phenotype and Chromosomal
Instability Are Inversely Correlated in Sporadic Colorectal Cancer. GASTROENTEROLOGY
2007;132:127-138-
50. Rodriguez J, Frigola J, Vendrell E és mtsai: Chromosomal Instability Correlates with Genome-wide
DNA Demethylation in Human Primary Colorectal Cancers. Cancer Res 2006; 66: 8462-8.
51. Nosho K, Yamamoto H, Mikami M és mtsai: Overexpression of poly (ADP-ribose) polymerase-1
(PARP-1) in the early stage of colorectal carcinogenesis. Eur J Cancer 2006;42:2374-81.
52. Roberts RL, Gearry RB, Allington MDE és mtsai: Caspase Recruitment Domain-Containing Protein 15
Mutations in Patients with Colorectal Cancer. Cancer Res 2006; 66: 2532-5.
53. Locker GY, Kaul K, Weinberg DS és mtsai: The I1307K APC polymorphism in Ashkenazi Jews with
colorectal cancer: clinical and pathologic features. Cancer Genet Cytogenet 2006;169:33-8.
54. Syngal S, Stoffel E, D Chung D, C Willett és mtsai: Detection of Stool DNA Mutations before and after
Treatment of Colorectal Neoplasia. Cancer 2006; 106:277-83
55. Watanabe T, Komuro Y, Kiyomatsu T és mtsai: Prediction of Sensitivity of Rectal Cancer Cells in
Response to Preoperative Radiotherapy by DNA Microarray Analysis of Gene Expression Profiles.
Cancer Res 2006; 66: 3370-4.
56. Neal CP, Garce G, Doucas H és mtsai: Molecular prognostic markers in resectable colorectal liver
metastases: A systematic review. Eur J Cancer 2006;42:1728-43.
57. Samowitz WS, Wolff RK, Curtin K és mtsai: Interactions Between CYP2C9 and UGT1A6
Polymorphisms and Nonsteroidal Anti-Inflammatory Drugs in Colorectal Cancer Prevention. Clin
Gastroenterol Hepatol 2006;4:894-904.
58. Massacesi C, Terrazzino S, Marcucci F és mtsai: Uridine Diphosphate Glucuronosyl Transferase 1A1
Promoter Polymorphism Predicts the Risk of Gastrointestinal Toxicity and Fatigue Induced by
Irinotecan-Based Chemotherapy. Cancer 2006;106:1007-16.
59. Gyorffy B, Surowiak P, Kiesslich O és mtsai: Gene expression profiling of 30 cancer cell lines predicts
resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer
2006;119:1699-1712.
60. Dotor E, Cuatrecases M, Martínez-Iniesta M és mtsai: Tumor Thymidylate Synthase 1494del6
Genotype As a Prognostic Factor in Colorectal Cancer Patients Receiving Fluorouracil-Based Adjuvant
Treatment. J Clin Oncol 2006; 24:1603-1611.
61*. IA Atencio, M Grace, R Bordens és mtsai: Biological activities of a recombinant adenovirus p53 (SCH
58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial. Cancer Gene
Therapy 2006; 13: 169-181.
62. L Zhao, A Dong, J Gu és mtsai: The antitumor activity of TRAIL and IL-24 with replicating oncolytic
adenovirus in colorectal cancer. Cancer Gene Therapy 2006;13:1011-22.
436 Gastro Update 2007
63. Vermeire S. Review article: Genetic susceptibility and application of genetic testing in clinical
management of inflammatory bowel disease Aliment Pharmacol Ther 2006; 24 (Suppl3): 2-10.
64. Siminovitch KA: Advances in the molecular dissection of inflammatory bowel disease Seminars
Immunol 2006;18 (4): 244-253.
65. Gaya DR, Russell RK, Nimmo ER, és mtsai: New genes in inflammatory bowel disease: lessons for
complex diseases? Lancet 2006;367 (9518):1271-1284.
66. Lakatos PL, Lakatos L.: Current concepts on the genetics and pharmacogenetics of inflammatory bowel
disease: do they help in clinical management? Current Genomics 2006;7:149-162.
67. Lakatos PL, Fischer S, Lakatos L, Gal I, Papp J.: Current concept on the pathogenesis of IBD: crosstalk
between genetic and microbial factors. Pathogenic bacteria, altered bacterial sensing or changes in
mucosal integrity take “toll”? World J Gastroenterol 2006;12:1829-40.
68*. Duerr RH, Taylor KD, Brant SR és mtsai: A Genome-Wide Association Study Identifies IL23R as an
Inflammatory Bowel Disease Gene. Science 2006;314:1461-63.
69. Hampe J, Franke A, Rosenstiel P és mtsai: A genome-wide association scan of nonsynonymous SNPs
identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007;39:207-11.
70. Van Bodegraven AA, Curley CR, Hunt KA és mtsai: Genetic Variation in Myosin IXB Is Associated
With Ulcerative Colitis. GASTROENTEROLOGY 2006;131:1768-1774.
71. Amundsen SS, Vatn M, Wijmenga C, és mtsai: Association analysis of MYO9B gene polymorphisms
and inflammatory bowel disease in a Norwegian cohort. Tissue Antigens 2006;68:249-52.
72. Fellermann K, Stange DE, Schaeffeler E, et al: A chromosome 8 gene-cluster polymorphism with low
human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet
2006;79:439-48.
73. GE Hume, EV Fowler, D Lincoln és mtsai: Angiotensinogen and transforming growth factor b1: novel
genes in the pathogenesis of Crohn’s disease. J Med Genet 2006;43:e51.
74. Özen SC, Dagli Ü, Kilic MY és mtsai: NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms
in Turkish patients with inflammatory bowel disease. J Gastroenterol 2006; 41:304-310.
75. Törkvist L, Noble CL, Lördal M és mtsai: Contribution of CARD15 variants in determining susceptibility
to Crohn’s disease in Sweden. Scand J Gastroenterol 2006;41:700-5.
76. Oostenbrug LE, Nolte IM, Oosterom E és mtsai: CARD15 in inflammatory bowel disease and Crohn’s
disease phenotypes: An association study and pooled analysis. Dig Liver Dis 2006;38:834-45.
77. S Buhner, C Buning, J Genschel és mtsai: Genetic basis for increased intestinal permeability in families
with Crohn’s disease: role of CARD15 3020insC mutation? Gut 2006;55:342-347.
78. McGovern DP, Butler H, Ahmad T, és mtsai: TUCAN (CARD8) Genetic Variants and Inflammatory
Bowel Disease. GASTROENTEROLOGY 2006;131:1190-1196.
79. Van Limbergen J, Russell RK, Nimmo ER, és mtsai: Contribution of the NOD1/CARD4 insertion/deletion
polymorphism +32656 to inflammatory bowel disease in Northern Europe. Inflamm Bowel Dis 2007
published online.
80. Tremelling M, Hancock L, Bredin F, és mtsai: Complex insertion/deletion polymorphism in NOD1
(CARD4) is not associated with inflammatory bowel disease susceptibility in East Anglia panel.
Inflamm Bowel Dis 2006;12:967-71.
81. Silverberg MS. OCTNs: Will the real IBD5 gene please stand up? World J Gastroenterol 2006;12:3678-81.
82. RK Russell, HE Drummond, E RNimmo és mtsai: Analysis of the influence of OCTN1/2 variants with
in the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.
Gut 2006;55:1114.1123.
83. S Waller, M Tremelling, F Bredin és mtsai: Evidence for association of OCTN genes and IBD5 with
ulcerative colitis. Gut 2006;55:809-814.
84. Palmieri O, Latiano A, Valvano R, és mtsai: Variants of OCTN1-2 cation transporter genes are associated
Genetika 437
with both Crohn’s disease and ulcerative colitis. Aliment Pharmacol Ther 2006;23:497-506.
85. Pearce AV, Fisher SA, Prescott AJ és mtsai: Investigation of association of the DLG5 gene with phenotypes
of inflammatory bowel disease in the British population. Int J Colorectal Dis published online.
86. Buning C, Geerdts L, Fiedler T és mtsai: DLG5 Variants in Inflammatory Bowel Disease. Am J
Gastroenterol 2006;101:786-792.
87. Medici V, Mascheretti S, Crouvher PJ és mtsai: Extreme heterogeneity in CARD15 and DLG5 Crohn
disease-associated polymorphisms between German and Norwegian populations. Eur J Hum Genet
2007;14:459-68.
88. PL Lakatos, S Fischer, K Claes és mstai: DLG5 R30Q is not associated with inflammatory bowel disease
in Hungarian IBD patients, but predicts clinical response to steroids in Crohn’s disease. Inflamm Bowel
Dis 2006;12:362-8.
89. Oostenbrug LE, Dijkstra G, Nolte IM és mtsai: Absence of association between the multidrug resistance
(MDR1) gene and inflammatory bowel disease. Scand J Gastroenterol 2006;41:1174-82.
90. S Fischer, PL Lakatos, L Lakatos, és mtsai: The ATP-binding Cassette Transporter ABCG2 (BCRP) and
ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype, response to
medical therapy or need for surgery in Hungarian patients with Inflammatory Bowel Diseases. Scand J
Gastroenterol, published online.
91. Ho GT, Soranzo N, Nimmo ER, és mtsai: ABCB1/MDR1 gene determines susceptibility and phenotype
in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.
Hum Mol Genet 2006;15:797-805.
92. Ardizzone S, Maconi G, Bianchi V, és mtsai: Multidrug resistance 1 gene polymorphism and susceptibility
to inflammatory bowel disease. Inflamm Bowel Dis 2007, published online.
93. Tello-Ruiz MK, Curley C, DelMonte T, és mtsai: Haplotype-based association analysis of 56 function
al candidate genes in the IBD6 locus on chromosome 19. Eur J Hum Genet 2007;14:780-90.
94. Egan LJ, Derijks LJJ, Hommes DW.: Pharmacogenomics in Inflammatory Bowel Disease. Clin
Gastroenterol Hepatol 2006;4:21-8.
95. Castro-Santos P, Suarez A, Lopez-Rivas L és mtsai: TNFá and IL-10 Gene Polymorphisms in
Inflammatory Bowel Disease. Association of -1082 AA Low Producer IL-10 Genotype with Steroid
Dependency. Am J Gastroenterol 2006;101:1039-1047.
96. Stocco G, Martelossi S, Sartor F és mtsai: Prevalence of Methylenetetrahydrofolate Reductase
Polymorphisms in Young Patients with Inflammatory Bowel Disease. Dig Dis Sci 2006;51:474-9.
97. Zelinkova Z, Derijks LJJ, Stockers PCF.: Inosine Triphosphate Pyrophosphatase and Thiopurine SMethyltransferase
Genotypes Relationship to Azathioprine-Induced Myelosuppression. Clin
Gastroenterol Hepatol 2006;4:44-9.
98. Y Kakuta, Y Kinouchi, K Negoro és mtsai: Association study of TNFSF15 polymorphisms in Japanese
patients with inflammatory bowel disease Gut 2006;55;1527-1528.
99. Zhu J, Xia B, Guo Q és mtsai: Distribution of signal transducer and activator of transcription 6 gene
G2964A polymorphism in Chinese patients with ulcerative colitis. J Gastroenterol Hepatol
2006;21:1954-7.
100. Tosa M, Negoro K, Kinouchi Y és mtsai: Lack of association between IBD5 and Crohn’s disease in
Japanese patients demonstrates population-specific differences in inflammatory bowel disease. Scand J
Gastroenterol 2006;41:48-53.
101. Ozaki K, Nagasaka T, Notohara K és mtsai: Heterogeneous microsatellite instability observed within
epithelium of ulcerative colitis. Int J Cancer 2006;119:2513-9.
102. M-B Bengtson, T Ronning, M H Vatn és mtsai: Irritable bowel syndrome in twins: genes and environment.
Gut 2006;55:1754-1759.
103. Andersen V, Cammileri M, Kim HJ és mtsai: Is There an Association Between GNb3—C825T
438 Gastro Update 2007
Genotype and Lower Functional Gastrointestinal Disorders? GASTROENTEROLOGY
2006;130:1985-1994.
104. Jiang ZD, DuPont HL, Garey K és mtsai: A Common Polymorphism in the Interleukin 8 Gene
Promoter Is Associated with Clostridium difficile Diarrhea. Am J Gastroenterol 2006;101:1112-1116.
105. Oh BK, Kim YJ, Park YN és mtsai: Quantitative Assessment of hTERT mRNA Expression in Dysplastic
Nodules of HBV-Related Hepatocarcinogenesis. Am J Gastroenterol 2006;101:831-838
106*. Llovet JP, Chen Y, Wurmbach E és mtsai: A Molecular Signature to Discriminate Dysplastic Nodules
From Early Hepatocellular Carcinoma in HCV Cirrhosis. GASTROENTEROLOGY 2006;131:1758-1767
107*. Poon TCW, Wong N, Lai PBS és mtsai: A Tumor Progression Model for Hepatocellular Carcinoma:
Bioinformatic Analysis of Genomic Data. GASTROENTEROLOGY 2006;131:1262-1270.
108*. Zucman-Rossi J, Jeannot E, Nhieu JTV és mtsai: Genotype—Phenotype Correlation in Hepatocellular
Adenoma: New Classification and Relationship With HCC. HEPATOLOGY 2006;43:515-524.
109. Herath NI, Legett BA, Macdonald GA.: Review of genetic and epigenetic alterations in hepatocarcinogenesis.
J Gastroenterol Hepatol 2006;15-21.
110. Coulouarn C, Gomez-Quiroz LE, Lee JS és mtsai: Oncogene-Specific Gene Expression Signatures at
Preneoplastic Stage in Mice Define Distinct Mechanisms of Hepatocarcinogenesis. HEPATOLOGY
2006;44:1003-1011.
111. Ogata H, Kobayashi T, Chinen T és mtsai: Deletion of the SOCS3 Gene in Liver Parenchymal Cells
Promotes Hepatitis—Induced Hepatocarcinogenesis. GASTROENTEROLOGY 2006;131:179-193.
112. Zindy PJ, L’Helgoualc’h A, Bonnier D és mtsai: Upregulation of the Tumor Suppressor Gene Menin in
Hepatocellular Carcinomas and Its Significance in Fibrogenesis. HEPATOLOGY 2006;44:1296-1307.
113. Castillo J, Erroba E, Perugorrýa MJ és mtsai: Amphiregulin Contributes to the Transformed
Phenotype of Human Hepatocellular Carcinoma Cells. Cancer Res 2006; 66: 6129-38.
114. Zhai Y, Zhou G, Deng G és mtsai: Estrogen Receptor a Polymorphisms Associated With Susceptibility
to Hepatocellular Carcinoma in Hepatitis B Virus Carriers. GASTROENTEROLOGY 2006; 130:2001-2009
115. Ladero JM, Martínez C, Garcýa-Martín E és mtsai: Glutathione S-transferase M1 and T1 genetic
polymorphisms are not related to the risk of hepatocellular carcinoma: A study in the Spanish population.
Eur J Cancer 2006;42:73-7.
116*. Hernandez-Alcoceba R, Sangro B, Prieto J.: Gene therapy of liver cancer. World J Gastroenterol 2006;
12: 6085-6097.
117. Torimura T, Ueno T, Kin M és mtsai: Gene Transfer of Kringle 1-5 Suppresses Tumor Development and
Improves Prognosis of Mice With Hepatocellular Carcinoma. GASTROENTEROLOGY 2006;130:
1301-1310.
118. Chen XP, Wang Q, Guan J, és mtsai: Reversing multidrug resistance by RNA interference through the
suppression of MDR1 gene in human hepatoma cells. World J Gastroenterol 2006; 12: 3332-3337.
119. Su CQ, Wang XH, Chen J, és mtsai: Antitumor activity of an hTERT promoterregulated tumor-selective
oncolytic adenovirus in human hepatocellular carcinoma. World J Gastroenterol 2006;12: 7613-7620.
120. Sieghart W, Losert D, Sabine Strommer S és mtsai: Mcl-1 overexpression in hepatocellular carcinoma:
A potential target for antisense therapy. J Hepatol 2006;44:151-7.
121. Chou1 CK, Hung JY, Liu JC és mtsai: An attenuated Salmonella oral DNA vaccine prevents the growth
of hepatocellular carcinoma and colon cancer that express a-fetoprotein. Cancer Gene Therapy 2006;
13: 746-752.
122. Zhao J, Zhang X, Shi M és mtsai: TIP30 Inhibits Growth of HCC Cell Lines and Inhibits HCC
Xenografts in Mice in Combination With 5-FU. HEPATOLOGY 2006;44:205-215.
123. Bonkovsky HL, Naishadam D, Lambrecht LW és mtsai: Roles of Iron and HFE Mutations on Severity
and Response to Therapy During Retreatment of Advanced Chronic Hepatitis C. GASTROENTEROLOGY
2006;131:1440-1451.
Genetika 439
124. Smith MW, Walters KA, Korth MJ és mtsai: Gene Expression Patterns That Correlate With Hepatitis C
and Early Progression to Fibrosis in Liver Transplant Recipients. GASTROENTEROLOGY 2006;130:
179-187.
125. Goyal A, Suneetha PV, Kumar GT, et al: CCR5Ä32 mutation does not infl uence the susceptibility to
HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C.
World J Gastroenterol 2006; 12 (29): 4721-4726.
126. Persico M, Capasso M, Persico E és mtsai: Interleukin-10 1082 GG polymorphism influences the
occurrence and the clinical characteristics of hepatitis C virus infection. J Hepatol 2006;45:779-85.
127. Cheong JY, Cho SW, Hwang IL és mtsai: Association between chronic hepatitis B virus infection and
interleukin-10, tumor necrosis factora gene promoter polymorphisms. J Gastroenterol Hepatol
2006;21:1163-9.
128. Karlsen TH, Lie BA, Froslie KF, és mtsai: Polymorphisms in the Steroid and Xenobiotic Receptor Gene
Influence Survival in Primary Sclerosing Cholangitis. GASTROENTEROLOGY 2006;131:781-787.
129. Karlsen TH, Hampe J, Wiencke K, és mtsai: Genetic polymorphisms associated with inflammatory
bowel disease do not confer risk for primary sclerosing cholangitis. Am J Gastroenterol 2007;102:115-21.
130. Bowlus CL, Karlsen TH, Broome U és mtsai: Analysis of MAdCAM-1 and ICAM-1 polymorphisms in
365 Scandinavian patients with primary sclerosing cholangitis. J Hepatol 2006;45:704-10.
131. Henckaerts L, Fevery J, Van Steenbergen W, és mtsai: CC-type chemokine receptor 5-Delta32 mutation
protects against primary sclerosing cholangitis. Inflamm Bowel Dis 2006;12:272-7.
132. Wiencke K, Boberg KM, Donaldson P, és mtsai: No major effect of the CD28/CTLA4/ICOS gene
region on susceptibility to primary sclerosing cholangitis. Scand J Gastroenterol 2006;41:586-91.
133. Richardet JP, Scherman E, Costa C és mtsai: Combined polymorphisms of tumour necrosis factor
alpha and interleukin-10 genes in patients with alcoholic hepatitis. Eur J Gastroenterol Hepatol 18:673-679
134. Gleeson D, Evans S, Bradley M és mtsai: HFE Genotypes in Decompensated Alcoholic Liver Disease:
Phenotypic Expression and Comparison with Heavy Drinking and with Normal Controls.
Am J Gastroenterol 2006;101:304-310
135. Day CP.: Genes or environment to determine alcoholic liver disease and nonalcoholic fatty liver disease.
Liver International 2006: 26: 1021-1028.
136. Donaldson PT, Baragiotta A, Heneghan MA és mtsai: HLA Class II Alleles, Genotypes, Haplotypes,
and Amino Acids in Primary Biliary Cirrhosis: A Large-Scale Study. HEPATOLOGY 2006;44:667-674.
137. Floreani A, Carderi I, Variola A és mtsai: A Novel Multidrug-Resistance Protein 2 Gene Mutation
Identifies a Subgroup of Patients With Primary Biliary Cirrhosis and Pruritus. HEPATOLOGY
2006;43:1152-1154.
138. Lovicu M, Dessi V, Lepori MB és mtsai: The canine copper toxicosis gene MURR1 is not implicated in
the pathogenesis of Wilson disease. J Gastroenterol 2006; 41:582-587
139. Walsh A, Dixon JL, Ramm GA és mtsai: The Clinical Relevance of Compound Heterozygosity for the
C282Y and H63D Substitutions in Hemochromatosis. Clin Gastroenterol Hepatol 2006;4:1403-10.
140. Farheen S, Sengupta S, Santra A, és mtsai: Gilbert’s syndrome: High frequency of the (TA)7TAA allele
in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDPglucuronosyltransferase
1 gene. World J Gastroenterol 2006; 12: 2269-2275.
141. Demeilliers C, Jacquemin E, Barbu V és mtsai: Altered Hepatobiliary Gene Expressions in PFIC1:
ATP8B1 Gene Defect Is Associated With CFTR Downregulation. HEPATOLOGY 2006;43:1125-1134.
142. Daly AK, Aithal GP, Leathart JBS és mtsai: Genetic Susceptibility to Diclofenac-Induced
Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes. GASTROENTEROLOGY
2007;132:272-281
143. Lyons MA, Wittenburg H.: Cholesterol Gallstone Susceptibility Loci: A Mouse Map, Candidate Gene
Evaluation, and Guide to Human LITH Genes. GASTROENTEROLOGY 2006;131:1943-1970
440 Gastro Update 2007
144. Qiang H, Lin Y, Zhang X, és mtsai: Differential expression genes analyzed by cDNA array in the regulation
of rat hepatic fibrogenesis. Liver International 2006: 26: 1126-1137.
145. Kaizu T, Ikeda A, Nakao A és mtsai: Donor Graft Adenoviral iNOS Gene Transfer Ameliorates Rat
Liver Transplant Preservation Injury and Improves Survival. HEPATOLOGY 2006;43:464-473
146. Sato N, Fukoshima N, Chang R és mtsai: Differential and Epigenetic Gene Expression Profiling
Identifies Frequent Disruption of the RELN Pathway in Pancreatic Cancers. GASTROENTEROLOGY
2006;130:548-565.
147. AE Szafranska, TS Davison, J John, és mtsai: MicroRNA expression alterations are linked to tumorigenesis
and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 2007 published online.
148. Watanabe H, Okada G, Ohtsubo K és mtsai: Aberrant methylation of secreted apoptosis-related protein 2
(SARP2) in pure pancreatic juice in the diagnosis of pancreatic neoplasms. Pancreas 2006;32:382-9.
149*. J Kim, H A Reber, S M Dry és mtsai: Unfavourable prognosis associated with K-ras gene mutation in
pancreatic cancer surgical margins. Gut 2006;55:1598-1605.
150. Marchese R, Muleti A, Pasqualetti P és mtsai: Low correspondence between K-ras mutations in pancreatic
cancer tissue and detection of K-ras mutations in circulating DNA. Pancreas 2006;32:171-7.
151. Li D, Frazier M, Evans DB és mtsai: Single Nucleotide Polymorphisms of RecQ1, RAD54L, and ATM
Genes Are Associated With Reduced Survival of Pancreatic Cancer. J Clin Oncol 2006;24:1720-1728.
152. Sato N, Fukushima N, Matsubayashi H és mtsai: Aberrant Methylation of Reprimo Correlates With
Genetic Instability and Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma. Cancer 2006;
107:251-7.
153. Schönleben F, Qui W, Bruckman KC és mtsai: BRAF and KRAS gene mutations in intraductal papillary
mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Letters in press.
154. Piepoli A, Gentile A, Valvano MR, és mtsai: Lack of association between UGT1A7, UGT1A9, ARP,
SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.
World J Gastroenterol 2006; 12: 6343-6348
155. Schmidt J, Ryschich E, Sievers E és mtsai: Telomerase-Specific T-Cells Kill Pancreatic Tumor Cells In
Vitro and In Vivo. Cancer 2006;106:759-64.
156. Y Ogura1, K Mizumoto1, E Nagai és mtsai: Peritumoral injection of adenovirus vector expressing NK4
combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer
cells implanted orthotopically in nude mice and prolongs survival. Cancer Gene Therapy 2006;13: 520-529
157. T Mizuno, M Nagao, Y Yamada és mtsai: Small interfering RNA expression vector targeting
hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers.
Cancer Gene Therapy 2006; 13: 131-140.
158. Ho PY, Shen IS, Chiu CT és mtsai: A Strong Association Between Down-Regulation of HLA-DR
Expression and the Late Mortality in Patients with Severe Acute Pancreatitis. Am J Gastroenterol
2006;101:1117-1124.
159. Felderbauer P, Klein W, Bulut K és mtsai: Mutations in the calcium-sensing receptor: A new genetic
risk factor for chronic pancreatitis? Scand J Gastroenterol 2006;41:343-8.
160. S Mahurkar, MM Idris, DN Reddy és mtsai: Association of cathepsin B gene polymorphisms with tropical
calcific pancreatitis. Gut 2006;55:1270-1275.
161. Bashkar S, Reddy DN, Mahurkar S és mtsai: Lack of significant association of an insertion/deletion
polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis.
BMC Gastroenterology 2006, 6:42.
162. Archer H, Jura N, Keller J és mtsai: A Mouse Model of Hereditary Pancreatitis Generated by
Transgenic Expression of R122H Trypsinogen. GASTROENTEROLOGY 2006;131:1844-1855
163. Sass DA, Papachristou GI, Lamd J és mtsai: The MCP-1 — 2518 A/G Polymorphism Is Not a
Susceptibility Factor for Chronic Pancreatitis. Pancreatology 2006;6:297-300.
